2017

Endocannabinoid signaling in the control of social behavior
Wei D, Allsop S, Tye K & Piomelli D
Trends in Neurosciences. 2017(online) ; dx.doi.org/10.1016/j.tins.2017.04.005 1 View PDF»

Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment
Burgos-Robles A, Kimchi E, Izadmehr E, Porzenheim MJ, Ramos-Guasp W, Nieh E, Felix-Ortiz A, Namburi P, Leppla C, Presbrey K, Anandalingam K, Pagan-Rivera P, Anahtar M, Beyeler A and Tye K
Nature Neuroscience. 24 April 2017(online) ; doi:10.1038/nn.4553 View PDF»

2016

Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation Nieh E, Vander Weele C, Matthews G, Presbrey K, Wichmann R, Leppla C, Izadmehr E, Wildes C and Tye K
Neuron. 2016 June 15; 90,1-13 doi:10.1016/j.neuron.2016.04.035 View PDF»

Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval 
Beyeler A, Namburi P, Glober G, Simonnet C, Calhoon G, Conyers G, Luck R,  Wildes C and Tye K
Neuron. 2016 April 20; 90,2,348–361 doi:10.1016/j.neuron.2016.03.004   View PDF»

Dorsal raphe dopamine neurons represent the experience of social isolation 
Matthews G, Nieh E, Vander Weele C, Halbert S, Pradhan R, Yosafat A, Glober G, Izadmehr E, Thomas R, Lacy G, Wildes C, Ungless M and Tye K
Cell. 2016 February 11; 164,4,617–631 doi:http://dx.doi.org/10.1016/j.cell.2015.12.040   View PDF»

Architectural representation of valence in the limbic system
Namburi P, Al-Hasani R, Calhoon G, Bruchas M and Tye K
Neuropsychopharmachology. Available online 5 February 2016; doi: NPP.2015.358  View PDF»

2015

Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex
Felix-Ortiz AF, Burgos-Robles A, Bhagat ND, Leppla CA and Tye KM
Neuroscience. Available online 21 July 2015; doi:10.1016/j.neuroscience.2015.07.041 View PDF»

Resolving the neural circuits of anxiety
Calhoon GG  & Tye KM
Nature Neuroscience. 2015 September 25; 18, 1394-1404 doi:10.1038/nn.4101 View PDF»

A circuit mechanism for differentiating positive and negative associations
Namburi P, Beyeler A, Yorozu S, Calhoon G, Halbert SA, Wichmann R, Holden S, Mertens K, Anahtar M, Felix-Ortiz A, Wickersham I, Gray J & Tye K
Nature. 2015 April 30; 520,675–678 doi:10.1038/nature14366 PubMed Link» View PDF»

Decoding neural circuits that control compulsive sucrose seeking
Nieh EH, Matthews GA, Allsop SA, Presbrey KN, Leppla CA, Wichmann R, Neve R, Wildes CP, and Tye KM
Cell. 2015 Jan 29; 160, 528–541 doi:10.1016/j.cell.2015.01.003. PubMed Link» View PDF»
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From circuits to behaviour in the amygdala
Janak PH & Tye KM
Nature. 2015 Jan 15; 517,284–292 doi:10.1038/nature14188. PMID:25592533 PubMed Link»  View PDF»
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Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice
Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR,  Arey RN, Enwright III JF, Jacobsen JPR, Kumar S, Remillard EM, Caron MG, Deisseroth K and McClung CA
Mol Psychiatry. 2015 Jan 6; 1359-4184/15 doi:10.1038/mp.2014.167.PMID:25560763. PubMed Link»  View PDF»

2014

Neural circuit reprogramming: A new paradigm for treating neuropsychiatric disease?
Tye KM.
Neuron. 2014 Sep 17;83(6):1259-1261. doi: 10.1016/j.neuron.2014.08.022.  PMID: 25233309. PubMed Link»  View PDF»

Noninvasive optical inhibition with a red-shifted microbial rhodopsin.
Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES.
Nat Neurosci. 2014 Aug;17(8):1123-9. doi: 10.1038/nn.3752. Epub 2014 Jul 6. PMID: 24997763. PubMed Link»

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits.
Allsop SA, Vander Weele CM, Wichmann R, Tye KM.
Front Behav Neurosci. 2014 Jul 16;8:241. doi: 10.3389/fnbeh.2014.00241. eCollection 2014. Review. PMID: 25076878. PubMed Link»  View PDF»

Natural neural projection dynamics underlying social behavior.
Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K.
Cell. 2014 Jun 19;157(7):1535-51. doi: 10.1016/j.cell.2014.05.017. PMID:24949967. PubMed Link»  View PDF»

Deciphering memory function with optogenetics.
Beyeler A, Eckhardt CA, Tye KM.
Prog Mol Biol Transl Sci. 2014;122:341-90. PMID: 24484707. PubMed Link»

PTEN knockdown alters dendritic spine/protrusion morphology, not density.
Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM.
J Comp Neurol. 2014 Apr 1;522(5):1171-90. doi: 10.1002/cne.23488. PMID: 24264880. PubMed Link»  View PDF»

Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior.
Felix-Ortiz AC, Tye KM.
J Neurosci. 2014 Jan 8;34(2):586-95. doi: 10.1523/JNEUROSCI.4257-13.2014. PMID: 24403157. PubMed Link»  View PDF»

2013

BLA to vHPC inputs modulate anxiety-related behaviors.
Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM.
Neuron. 2013 Aug 21;79(4):658-64. doi: 10.1016/j.neuron.2013.06.016. PMID: 23972595. PubMed Link»  View PDF»

Progress in understanding mood disorders: optogenetic dissection of neural circuits.
Lammel S, Tye KM, Warden MR.
Genes Brain Behav. 2013 May 17. doi: 10.1111/gbb.12049. [Epub ahead of print] PMID: 23682971. PubMed Link»  View PDF»

Diverging neural pathways assemble a behavioural state from separable features in anxiety.
Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K.
Nature. 2013 Apr 11;496(7444):219-23. doi: 10.1038/nature12018. Epub 2013 Mar 20. PubMed Link»  View PDF»

Dopamine neurons modulate neural encoding and expression of depression-related behaviour.
Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K.
Nature. 2013 Jan 24;493(7433):537-41. doi: 10.1038/nature11740. Epub 2012 Dec 12. PubMed Link»  View PDF»

2012

Glutamate inputs to the nucleus accumbens: does source matter?
Tye KM.
Neuron. 2012 Nov 21;76(4):671-3. PubMed Link»  View PDF»

A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K.
Nature. 2012 Dec 20;492(7429):428-32. PubMed Link»  View PDF»

Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors.
Nieh EH, Kim SY, Namburi P, Tye KM.
Brain Res. 2012 Nov 8; (12)01776-3. PubMed Link»  View PDF»

Input-specific control of reward and aversion in the ventral tegmental area.
Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC.
Nature. 2012 Nov 8;491(7423):212-7. PubMed Link»  View PDF»

Optogenetic investigation of neural circuits underlying brain disease in animal models.
Tye KM, Deisseroth K.
Nat Rev Neurosci. 2012 Mar 20;13(4):251-66. PubMed Link»  View PDF»

GABA neurons of the VTA drive conditioned place aversion.
Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouebe G, Deisseroth K, Tye KM, Luscher C.
Neuron. 2012 Mar 22; 73(6): 1173–83. PubMed Link»  View PDF»

2011

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.
Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O’Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K.
Nat Methods. 2011 Dec 18. doi: 10.1038/nmeth.1808. PubMed Link»  View PDF»

Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.
Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K.
Neuron. 2011 Dec 8;72(5):721-33. PubMed Link»  View PDF»

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.
Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A.
Nature. 2011 Jun 29;475(7356):377-80. PubMed Link»  View PDF»

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels.
Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG.
Proc Natl Acad Sci. 2011 May 3;108(18):7595-600. PubMed Link»  View PDF»

Amygdala circuitry mediating reversible and bidirectional control of anxiety.
Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K.
Nature. 2011 Mar 17;471(7338):358-62. PubMed Link»  View PDF»

2010

Neuroplastic alterations in the limbic system following cocaine or alcohol exposure.
Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A.
Curr Top Behav Neurosci. 2010;3:3-27. PubMed Link»  View PDF»

Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.
Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye KM, Bonci A.
Neuron. 2010 Mar 11;65(5):682-94. PubMed Link»  View PDF»

Methylphenidate facilitates learning-induced amygdala plasticity.
Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A.
Nat Neurosci. 2010 Apr;13(4):475-81. PubMed Link»  View PDF»

Amygdala neural encoding of the absence of reward during extinction.
Tye KM, Cone JJ, Schairer WW, Janak PH.
J Neurosci. 2010 Jan 6;30(1):116-25. PubMed Link»  View PDF»

2008

Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning.
Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH.
Nature. 2008 Jun 26;453(7199):1253-7. PubMed Link»  View PDF»

2007

Amygdala neurons differentially encode motivation and reinforcement.
Tye KM, Janak PH.
J Neurosci. 2007 Apr 11;27(15):3937-45. PubMed Link»  View PDF»