2018

Dopamine tunes prefrontal outputs to orchestrate aversive processing.
Vander Weele C, Siciliano C & Tye K.
Brain Res. 2018 Dec 1. doi:10.1016/j.brainres.2018.11.044 Read PDF »

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli.
Vander Weele C, Siciliano C, Matthews G, Namburi P, Izadmehr E, Espinel I, Nieh E, Schut E, Padilla-Coreano N, Burgos-Robles A, Chang CJ, Kimchi E, Beyeler A, Wichmann R, Wildes C & Tye K.
Nature. 2018 Nov 7. doi:10.1038/s41586-018-0682-1 Read PDF »

Neural Circuit Motifs in Valence Processing.
Tye K.
Neuron. 2018 Oct. 24. doi:10.1016/j.neuron.2018.10.001 Read PDF »

Clustering Time Series with Nonlinear Dynamics: A Bayesian Non-Parametric and Particle-Based Approach.
Lin A, Zhang Y, Heng J, Allsop S, Tye K, Jacob P & Ba D.
arXiv. 2018 Oct 23. arXiv:1810.09920v2 Read PDF »

Double threat in striatal dopamine signaling.
Siciliano C, Mills F & Tye K.
Nature neuroscience. 2018 Sept 26. doi:10.1038/s41593-018-0243-9 Read PDF »

Sequential Detection of Regime Changes in Neural Data.
Banerjee T, Allsop S, Tye K, Ba D & Tarokh V.
arXiv. 2018 Sept 2. arXiv:1809.00358 Read PDF »

Leveraging calcium imaging to illuminate circuit dysfunction in addiction.
Siciliano C & Tye K.
Alcohol. 2018 June 6. doi:10.1016/j.alcohol.2018.05.013 Read PDF »

Corticoamygdala transfer of socially derived information gates observational learning.
Allsop S, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, C. Felix-Ortiz A, Vienne A, Beyeler A, Izadmehr E, Glober G, Cum M, Stergiadou J, Anandalingam K, Farris K, Namburi P, Leppla C, Weddington J, Nieh E, Smith A, Ba D, Brown E & Tye K.
Cell. 2018 May 3,. doi:10.1016/j.cell.2018.04.004. Read PDF »

Acute Food Deprivation Rapidly Modifies Valence-Coding Microcircuits in the Amygdala.
Gwendolyn G Calhoon, Amy K Sutton, Chia-Jung Chang, Avraham M Libster, Gordon F Glober, Clémentine L Lévêque, G David Murphy, Praneeth Namburi, Christopher A Leppla, Cody A Siciliano, Craig P Wildes, Eyal Y Kimchi, Anna Beyeler & Kay M Tye
BioRxiv. 2018 Mar. 19,. doi:10.1101/285189 Read PDF »

Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting or projection neurons.
Chatterjee S, Sullivan H, MacLennan B, Xu R, Hou Y, Lavin  T, Lea N, Michalski J, Babcock K, Dietrich S, Matthews G, Beyeler A, Calhoon G, Glober G, Whitesell J, Yao S, Cetin  A, Harris J, Zeng H, Tye K, Reid RC & Wickersham  I.
Nature Neuroscience. 2018 March 5, doi:10.1038/s41593-018-0091-7. Read PDF »

Editorial Overview: Neurobiology of Behavior.
Tye K & Uchida N.
Current Opinion in Neurobiology. 2018 March, 49, doi:10.1016/j.conb.2018.02.019. Read PDF »

Organization of valence-encoding and projection-defined neurons in the basolateral amygdala.
Beyeler A, Chang CJ, Silvestre M, Lévêque C, Namburi P,  Wildes C & Tye K.
Cell Reports. 2018 Jan, 22:905-922, doi:10.1016/j.celrep.2017.12.097. Read PDF »

2017

Acute stress induces long-lasting alterations in the dopaminergic system in female mice.
Wichmann R, Vander Weele C, Yosafat A, Schut E, Verharen J, Sridharma S, Siciliano C, Izadmehr E, Farris K, Wildes C, Kimchi E  & Tye K.
BioRxiv. 2017 July, preprint, doi: https://doi.org/10.1101/168492.  Read PDF »

A light- and calcium-gated transcription factor for imaging and manipulating activated neurons.
Wang W,  Wildes C, Pattarabanjird T, Sanchez M, Glober G, Matthews G, Tye K & Ting A.
Nature Biotechnology. 2017 Sep, 35(9):864-871, doi: 10.1038/nbt.3909, Epub 2017 Jun 26. PubMed »  Read PDF »

Endocannabinoid signaling in the control of social behavior.
Wei D, Allsop S, Tye K & Piomelli D.
Trends in Neurosciences. 2017 Jul, 40(7):385-396, doi: 10.1016/j.tins.2017.04.005, Epub 2017 May 26. PubMed »  Read PDF »

Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment.
Burgos-Robles A, Kimchi E, Izadmehr E, Porzenheim MJ, Ramos-Guasp W, Nieh E, Felix-Ortiz A, Namburi P, Leppla C, Presbrey K, Anandalingam K, Pagan-Rivera P, Anahtar M, Beyeler A and Tye K.
Nature Neuroscience. 2017 Jun, 20(6):824-835, doi: 10.1038/nn.4553, Epub 2017 Apr 24. PubMed »  Read PDF »

2016

Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation.
Nieh E, Vander Weele C, Matthews G, Presbrey K, Wichmann R, Leppla C, Izadmehr E, Wildes C and Tye K.
Neuron.016 Jun 15, 90(6):1286-1298, doi: 10.1016/j.neuron.2016.04.035, Epub 2016 May 26. PubMed »  Read PDF »

Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval.
Beyeler A, Namburi P, Glober G, Simonnet C, Calhoon G, Conyers G, Luck R,  Wildes C and Tye K.
Neuron. 2016 Apr 20, 90(2):348-361, doi: 10.1016/j.neuron.2016.03.004, Epub 2016 Mar 31. PubMed »  Read PDF »

Dorsal raphe dopamine neurons represent the experience of social isolation.
Matthews G, Nieh E, Vander Weele C, Halbert S, Pradhan R, Yosafat A, Glober G, Izadmehr E, Thomas R, Lacy G, Wildes C, Ungless M and Tye K
Cell. 2016 Feb 11, 164(4):617-31, doi: 10.1016/j.cell.2015.12.040. PubMed »  Read PDF »

Architectural representation of valence in the limbic system.
Namburi P, Al-Hasani R, Calhoon G, Bruchas M and Tye K
Neuropsychopharmachology. 2016 Jun, 41(7):1697-715, doi: 10.1038/npp.2015.358, Epub 2015 Dec 9. PubMed »  Read PDF »

2015

Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex.
Felix-Ortiz AF, Burgos-Robles A, Bhagat ND, Leppla CA and Tye KM.
Neuroscience. 2016 May 3, 321:197-209, doi: 10.1016/j.neuroscience.2015.07.041, Epub 2015 Jul 21. PubMed »  Read PDF »

Resolving the neural circuits of anxiety.
Calhoon GG  & Tye KM.
Nature Neuroscience. 2015 Oct, 18(10):1394-404, doi: 10.1038/nn.4101, Epub 2015 Sep 25. PubMed »  Read PDF »

A circuit mechanism for differentiating positive and negative associations.
Namburi P, Beyeler A, Yorozu S, Calhoon G, Halbert SA, Wichmann R, Holden S, Mertens K, Anahtar M, Felix-Ortiz A, Wickersham I, Gray J & Tye K.
Nature.  2015 Apr 30, 520(7549):675-8, doi: 10.1038/nature14366. PubMed »  Read PDF »

Decoding neural circuits that control compulsive sucrose seeking.
Nieh EH, Matthews GA, Allsop SA, Presbrey KN, Leppla CA, Wichmann R, Neve R, Wildes CP, and Tye KM.
Cell. 2015 Jan 29, 160(3):528-41, doi: 10.1016/j.cell.2015.01.003. PubMed »  Read PDF »

From circuits to behaviour in the amygdala.
Janak PH & Tye KM.
Nature. 2015 Jan 15, 517(7534):284-92, doi: 10.1038/nature14188. PubMed »  Read PDF»

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.
Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR,  Arey RN, Enwright III JF, Jacobsen JPR, Kumar S, Remillard EM, Caron MG, Deisseroth K and McClung CA.
Mol Psychiatry. 2015 Nov, 20(11):1406-19, doi: 10.1038/mp.2014.167, Epub 2015 Jan 6. PubMed »  Read PDF »

2014

Neural circuit reprogramming: A new paradigm for treating neuropsychiatric disease?
Tye KM.
Neuron. 2014 Sep 17, 83(6):1259-61, doi: 10.1016/j.neuron.2014.08.022. PubMed »  Read PDF »

Noninvasive optical inhibition with a red-shifted microbial rhodopsin.
Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES.
Nature Neuroscience. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. PubMed » Read PDF »

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits.
Allsop SA, Vander Weele CM, Wichmann R, Tye KM.
Frontiers in Behavioral Neuroscience. 2014 Jul 16, 8:241, doi: 10.3389/fnbeh.2014.00241, eCollection 2014. PubMed »  Read PDF »

Natural neural projection dynamics underlying social behavior.
Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K.
Cell. 2014 Jun 19, 157(7):1535-51, doi: 10.1016/j.cell.2014.05.017. PubMed »  Read PDF »

Deciphering memory function with optogenetics.
Beyeler A, Eckhardt CA, Tye KM.
Progress in Molecular Biology and Translational Science. 2014, 122:341-90, doi: 10.1016/B978-0-12-420170-5.00012-X. PubMed »

PTEN knockdown alters dendritic spine/protrusion morphology, not density.
Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM.
The Journal of Comparative Neurology. 2014 Apr 1, 522(5):1171-90, doi: 10.1002/cne.23488. PubMed »  Read PDF »

Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior.
Felix-Ortiz AC, Tye KM.
The Journal of Neuroscience. 2014 Jan 8, 34(2):586-95, doi: 10.1523/JNEUROSCI.4257-13.2014. PubMed »  Read PDF »

2013

BLA to vHPC inputs modulate anxiety-related behaviors.
Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM.
Neuron. 2013 Aug 21, 79(4):658-64, doi: 10.1016/j.neuron.2013.06.016. PubMed »  Read PDF »

Progress in understanding mood disorders: optogenetic dissection of neural circuits.
Lammel S, Tye KM, Warden MR.
Genes, Brain, and Behavior. 2014 Jan, 13(1):38-51, doi: 10.1111/gbb.12049, Epub 2013 Jun 11. PubMed »  Read PDF »

Diverging neural pathways assemble a behavioural state from separable features in anxiety.
Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K.
Nature. 2013 Apr 11, 496(7444):219-23, doi: 10.1038/nature12018, Epub 2013 Mar 20. PubMed »  Read PDF »

Dopamine neurons modulate neural encoding and expression of depression-related behaviour.
Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K.
Nature. 2013 Jan 24, 493(7433):537-541, doi: 10.1038/nature11740, Epub 2012 Dec 12. PubMed »  Read PDF »

2012

Glutamate inputs to the nucleus accumbens: does source matter?
Tye KM.
Neuron. 2012 Nov 21, 76(4):671-3, doi: 10.1016/j.neuron.2012.11.008. PubMed »  Read PDF »

A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K.
Nature. 2012 Dec 20, 492(7429):428-32, doi: 10.1038/nature11617. PubMed »  Read PDF »

Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors.
Nieh EH, Kim SY, Namburi P, Tye KM.
Brain Research. 2013 May 20, 1511:73-92, doi: 10.1016/j.brainres.2012.11.001, Epub 2012 Nov 8.. PubMed »  Read PDF »

Input-specific control of reward and aversion in the ventral tegmental area.
Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC.
Nature. 2012 Nov 8, 491(7423):212-7, doi: 10.1038/nature11527, Epub 2012 Oct 14. PubMed »  Read PDF »

Optogenetic investigation of neural circuits underlying brain disease in animal models.
Tye KM, Deisseroth K.
Nature Reviews Neuroscience. 2012 Mar 20, 13(4):251-66, doi: 10.1038/nrn3171. PubMed »  Read PDF »

GABA neurons of the VTA drive conditioned place aversion.
Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouebe G, Deisseroth K, Tye KM, Luscher C.
Neuron. 2012 Mar 22, 73(6):1173-83, doi: 10.1016/j.neuron.2012.02.015, Epub 2012 Mar 21. PubMed »  Read PDF »

2011

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.
Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O’Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K.
Nature Methods. 2011 Dec 18, 9(2):159-72, doi: 10.1038/nmeth.1808. PubMed »  Read PDF »

Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.
Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K.
Neuron. 2011 Dec 8, 72(5):721-33, doi: 10.1016/j.neuron.2011.10.028. PubMed »  Read PDF »

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.
Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A.
Nature. 2011 Jun 29, 475(7356):377-80, doi: 10.1038/nature10194. PubMed »  Read PDF »

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels.
Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG.
Proceedings of the National Academy of Sciences of the United States of America. 2011 May 3, 108(18):7595-600, doi: 10.1073/pnas.1017210108, Epub 2011 Apr 19. PubMed »  Read PDF »

Amygdala circuitry mediating reversible and bidirectional control of anxiety.
Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K.
Nature. 2011 Mar 17, 471(7338):358-62, doi: 10.1038/nature09820, Epub 2011 Mar 9. PubMed »  Read PDF »

2010

Neuroplastic alterations in the limbic system following cocaine or alcohol exposure.
Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A.
Current Topics in Behavioral Neurosciences. 2010, 3:3-27, doi: 10.1007/7854_2009_23. PubMed »  View PDF »

Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.
Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye KM, Bonci A.
Neuron. 2010 Mar 11m 65(5):682-94, doi: 10.1016/j.neuron.2010.02.015. PubMed »  View PDF »

Methylphenidate facilitates learning-induced amygdala plasticity.
Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A.
Nature Neuroscience. 2010 Apr, 13(4):475-81, doi: 10.1038/nn.2506, Epub 2010 Mar 7. PubMed »  View PDF »

Amygdala neural encoding of the absence of reward during extinction.
Tye KM, Cone JJ, Schairer WW, Janak PH.
The Journal of neuroscience. 2010 Jan 6, 30(1):116-25, doi: 10.1523/JNEUROSCI.4240-09.2010. PubMed »  View PDF »

2008

Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning.
Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH.
Nature. 2008 Jun 26, 453(7199):1253-7, doi: 10.1038/nature06963, Epub 2008 May 11. PubMed »  View PDF »

2007

Amygdala neurons differentially encode motivation and reinforcement.
Tye KM, Janak PH.
The Journal of Neuroscience. 2007 Apr 11, 27(15):3937-45. PubMed »  Read PDF »