Brain circuitry of positive vs negative memories discovered in mice

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Prior to the new study, scientists suspected involvement of the circuits ultimately implicated, but were stumped by a seeming paradox. A crossroads of convergent circuits in an emotion hub deep in the brain, thebasolateral amygdala, seem to be involved in both fear and reward learning, but how one brain region could orchestrate such opposing behaviors … Read More

Neurons that tell good from bad identified

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MIT scientists, including one of Indian-origin, have identified two populations of neurons in the amygdala that process positive and negative emotions. These neurons relay the information to other brain regions that initiate the appropriate behavioral response, said neuroscientists from Massachusetts Institute of Technology’s Picower Institute for Learning and Memory. “How do we tell if something … Read More

Distinct Amygdala Projections Control Opposing Behavioral Outputs

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Monday Night Neuroscience Seminars – Kay Tye, MIT – “Distinct Amygdala Projections Control Opposing Behavioral Outputs” The ability to differentiate between positive and negative environmental stimuli is critical to an animal’s survival. However, the neural circuits that endow the brain with the ability to differentiate positive and negative motivationally significant stimuli have been difficult to … Read More

Brain circuit can tune anxiety

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Brain circuit can tune anxiety

New findings may help neuroscientists pinpoint better targets for antianxiety treatments. Anxiety disorders, which include posttraumatic stress disorder, social phobias and obsessive-compulsive disorder, affect 40 million American adults in a given year. Currently available treatments, such as antianxiety drugs, are not always effective and have unwanted side effects. To develop better treatments, a more specific … Read More