Brain circuitry of positive vs negative memories discovered in mice

News

Prior to the new study, scientists suspected involvement of the circuits ultimately implicated, but were stumped by a seeming paradox. A crossroads of convergent circuits in an emotion hub deep in the brain, thebasolateral amygdala, seem to be involved in both fear and reward learning, but how one brain region could orchestrate such opposing behaviors … Read More

Creative Minds: Trying to Curb Those Sugar Cravings

News

Creative Minds Trying to Curb hose Sugar Cravings

It’s that time of year again: holiday parties and family feasts! One of the most frequently made—and most often broken—New Year’s resolutions is to follow a sensible diet. All goes well until you catch sight of a cupcake or smell some cookies fresh out of the oven. Sensory cues trigger cravings that crumble resolve and, … Read More

Dissecting neural circuits underlying behaviors relevant to psychiatric disease in animal models

Events

Kay Tye gave a talk at Harvard University: “Dissecting neural circuits underlying behaviors relevant to psychiatric disease in animal models”. The ability to differentiate between positive and negative environmental stimuli is critical to an animal’s survival.  However, the  neural circuits that endow the brain with the ability to differentiate positive and negative motivationally significant stimuli have been … Read More

Three from MIT win NIH grants

News, Press Releases

Boyden, Ting and Tye receive grants for innovative medical research. Three MIT faculty members have been awarded National Institutes of Health (NIH) grants designed to promote innovative biomedical research. The Institute’s recipients of these NIH grants are Edward Boyden, an associate professor of biological engineering and brain and cognitive sciences; Alice Ting, the Ellen Swallow … Read More

With NIH grant, Kay Tye will take on obesity

News, Press Releases

The MIT professor has earned a 2013 NIH Director’s New Innovator Award to further her obesity research. MIT assistant professor of neuroscience Kay M. Tye has studied the brain circuits underlying addiction, anxiety and depression — major problems to the health of individuals and society. Now she wants to apply her training, and her own … Read More

Brain circuit can tune anxiety

Press Releases

Brain circuit can tune anxiety

New findings may help neuroscientists pinpoint better targets for antianxiety treatments. Anxiety disorders, which include posttraumatic stress disorder, social phobias and obsessive-compulsive disorder, affect 40 million American adults in a given year. Currently available treatments, such as antianxiety drugs, are not always effective and have unwanted side effects. To develop better treatments, a more specific … Read More

Dissecting the Neural Circuits Mediating Anxiety

News

Neurostimulation as a tool for Basic Science and Medicine.  Anxiety disorders are the single most-common class of psychiatric diseases, afflicting up to 28% of the adult population. Although human imaging studies have implicated the amygdala in anxiety, little is known about the functional role of individual microcircuits and distal circuits in terms of their individual … Read More

An On-Off Switch for Anxiety

News

An On-Off Switch for Anxiety

Researchers discover a brain circuit that can instantly dampen—or exacerbate—anxiety in mice. With the flick of a precisely placed light switch, mice can be induced to cower in a corner in fear or bravely explore their environment. The study highlights the power of optogeneticstechnology—which allows neuroscientists to control genetically engineered neurons with light—to explore the … Read More